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1) A set of well identified inflammatory biomarkers (IL-6, TNF-α, IL-1β, IFN-α, neutrophil and NET biomarkers) 2) Additional biomarkers including the awakening cortisol response, zonulin, tryptophan, kynurenine 3) Key quantified questionnaire-based symptoms (fatigue, ability to concentrate and to memorize) and number of symptoms 4) Functional tests including HRV, VO 2max , orthostatic intolerance and cognitive tests